Just putting in my two cents as someone who works as a pharmacist IRL, I haven't looked over much of the page, but I checked out what SR was referencing, and yeah, he's right. Blood vessels contracting would prevent blood from flowing properly, leading to severe hypotension, organ failure, and eventually, coma and death.
EDIT: Looking over it further, a lot of the explanations behind the mechanisms of the drugs don't make any sense, and in those cases I'd say it's probably better to just handwave it since you'd need a doctorate to describe / understand the pharmacokinetics anyway. I also noticed that you have mood stabilizers under both "physical" and "mental" enhancements. How come?
If you want to, you can contact me on IRC, and I can help you flesh things out more.