Okay, so Leutre (a headstrong individualist with a penchant for barfights) and Miyoko (snarky mature woman) go out and tour the galaxy in a starship doing random things on their next vacation? Somebody find me a blonde guy who jokes about everything, a half-insane gun maniac, a spunky female mechanic, a priest, a doctor, a schizophrenic loli, a classy whore, and a good reason for them to get one of those NAM Firefly-class miners, and we've got ourselves the Serenity* plotship.
*any similarities between the Serenity plotship and a TV show about a Firefly-class ship named Serenity containing a headstrong individualist with a penchant for barfights, a snarky mature woman, a blonde guy who jokes about everything, a half-insane gun maniac, a spunky female mechanic, a priest, a doctor, a schizophrenic loli, and a classy whore are purely coincidental.